Author(s): Moreira, Xavier ; Santos, Patrícia ; Faustino, M. Amparo F. ; Raposo, M. Manuela M. ; Costa, Susana P.G. ; Moura, Nuno M.M. ; Gomes, Ana T.P.C. ; Almeida, Adelaide ; Neves, M.G.P.M.S.
Date: 2020
Persistent ID: http://hdl.handle.net/10773/36755
Origin: RIA - Repositório Institucional da Universidade de Aveiro
Subject(s): Porphyrin; N-Heterocycles; Photosensitizer; Antimicrobial photodynamic therapy; Gram-negative E. coli
New porphyrin-imidazole derivatives were synthesised by Radziszewski reaction between 2-formyl-5,10,15,20-tetraphenylporphyrin 1 and several (hetero)aromatic 1,2-diones, which after cationization afforded promising monocationic photosensitizers 3a-d. Singlet oxygen studies have demonstrated that all the cationic porphyrin-imidazole conjugates 3a–d were capable to produce cytotoxic species. These photosensitizers were able to photoinactivate Eschericha coli and their inactivation profile was improved in the presence of KI.
