Autor(es): Jerónimo, M ; Moinho, R ; Nunes-Vicente, I ; Oliveira, A ; Dias, A ; Mimoso, G ; Dinis, I ; Mirante, A ; Faria, D
Data: 2014
Identificador Persistente: http://hdl.handle.net/10400.4/1828
Origem: Repositório do Centro Hospitalar e Universitário de Coimbra
Assunto(s): Hipertiroidismo; Doenças do Feto; Diagnóstico Prenatal
Graves’ disease is the main cause of hyperthyroidism in women of childbearing age. It occurs by the presence of serum immunoglobulins which stimulate the thyrotropin receptor (TRAbs) and may cross the placenta. It has serious consequences when uncontrolled, leading to fetal and/or neonatal hyperthyroidism or hypothyroidism. The authors describe the case of a newborn from a mother with poorly controlled Graves’ disease during pregnancy. He had an uneventful early neonatal period but developed hyperthyroidism in the second week of life. He was treated for two days with propranolol to manage tachycardia and metimazol during 4 months, with favourable clinical and laboratory outcome. During pregnancy, it is essential to control thyroid function and TRAbs in women with Graves’ disease. Newborns should be screened for thyroid function at birth and must have a regular follow up as it allows the diagnosis of transient hyperthyroidism or hypothyroidism and its early treatment, avoiding short and long term complications. Based on this case and literature review, the authors present a proposal of protocol in infants born to mothers with Graves’ disease.
