Author(s):
Antunes, Sandra ; Domingos, Ana
Date: 2023
Persistent ID: http://hdl.handle.net/10362/154296
Origin: Repositório Institucional da UNL
Subject(s): tick control; vaccine; “concealed” antigen; “exposed” antigen; QR180 Immunology; QR Microbiology; RA0421 Public health. Hygiene. Preventive Medicine; RM Therapeutics. Pharmacology; Immunology and Allergy; Molecular Biology; Immunology and Microbiology(all); Microbiology (medical); Infectious Diseases; SDG 3 - Good Health and Well-being; SDG 9 - Industry, Innovation, and Infrastructure
Description
Funding Information: The authors would like to thank FCT for funding the R&D Centre, Global Health and Tropical Medicine (GHTM—UID/04413/2020). Publisher Copyright: © 2023 by the authors.
Anti-tick vaccines development mainly depends on the identification of suitable antigens, which ideally should have different features. These should be key molecules in tick biology, encoded by a single gene, expressed across life stages and tick tissues, capable of inducing B and T cells to promote an immunological response without allergenic, hemolytic, and toxic effects; and should not be homologous to the mammalian host. The discussion regarding this subject and the usefulness of “exposed” and “concealed” antigens was effectively explored in the publication by Nuttall et al. (2006). The present commentary intends to debate the relevance of such study in the field of tick immunological control.
