Author(s):
Shen, Jie ; Valentim, Wander ; Friligkou, Eleni ; Overstreet, Cassie ; Choi, Karmel W. ; Koller, Dora ; O’Donnell, Christopher J. ; Stein, Murray B. ; Gelernter, Joel ; Koenen, Karestan C. ; Ressler, Kerry J. ; Zwart, John Anker ; Zoellner, Lori A. ; Zhao, Hongyu ; Zervas, Mark ; Zai, Clement C. ; Zai, Clement C. ; Young, Keith A. ; Young, Ross Mc D. ; Yehuda, Rachel ; Xiong, Ying ; Xia, Yan ; Wolf, Christiane ; Wolf, Erika J. ; Winternitz, Sherry ; Winsvold, Bendik S. ; Williamson, Douglas E. ; Williams, Michelle A. ; Werge, Thomas ; Wendt, Frank R. ; Weber, Heike ; Waszczuk, Monika ; Wang, Yunpeng ; Wang, Zhewu ; Voisey, Joanne ; Vinkers, Christiaan H. ; Vermetten, Eric ; van Rooij, Sanne J.H. ; Van Hooff, Miranda ; van den Heuvel, Leigh Luella ; Valdimarsdóttir, Unnur ; Ursano, Robert J. ; Uddin, Monica ; Trapido, Edward ; Tiwari, Arun K. ; Thompson, Wesley K. ; Teicher, Martin H. ; Sumner, Jennifer A. ; JM, Caldas-de-Almeida ; Stevens, Jennifer S.
Date: 2025
Persistent ID: http://hdl.handle.net/10362/188430
Origin: Repositório Institucional da UNL
Subject(s): Chemistry(all); Biochemistry, Genetics and Molecular Biology(all); General; Physics and Astronomy(all)
Description
: AOD 16037; Federally Qualified Health Centers: HHSN 263201600085U; Data and Research Center: 5 U2C OD023196; Biobank: 1 U24 OD023121; The Participant Center: U24 OD023176; Participant Technology Systems Center: 1 U24 OD023163; Communications and Engagement: 3 OT2 OD023205; 3 OT2 OD023206; and Community Partners: 1 OT2 OD025277; 3 OT2 OD025315; 1 OT2 OD025337; 1 OT2 OD025276. Funding Information: The CVD phenotype datasets utilized in this study were sourced from the MVP (see data availability), a nationwide initiative sponsored by the Department of Veterans Affairs Office of Research and Development. In our investigation of the genetic overlap between PTSD and cardiovascular clinical outcomes, we leveraged summary statistics from GWAS of EHR-based phecodes. Phecodes are manually curated groups of International Classification of Diseases (ICD) codes-9/10, designed to capture clinically meaningful concepts for research purposes using the PheMap, which classifies diagnoses into 17 categories (available at https://phewascatalog.org/ ). We tested 141 diagnoses from circulatory and 105 from endocrine/metabolic categories. A detailed description of GWAS of these traits in 458,203 individuals of European genetic ancestry in MVP is available elsewhere. (Supplementary Data ). Publisher Copyright: © The Author(s) 2025.
Patients with post-traumatic stress disorder face increased cardiovascular risk. This study examines shared genetic regions between post-traumatic stress disorder and 246 cardiovascular conditions across electronic health records, 82 cardiac imaging, and health behaviors defined by Life’s Essential 8. Post-traumatic stress disorder is genetically correlated with cardiovascular diagnoses in 33 regions, imaging traits in 4 regions, and health behaviors in 44 regions. Potentially shared causal variants between post-traumatic stress disorder and 17 cardiovascular conditions were observed in 11 regions. Subsequent observational analysis in AllofUS cohort showed post-traumatic stress disorder is associated with 13 diagnoses even after accounting for socioeconomic factors and depression. Genetically regulated proteome expression in brain and blood tissues identified 33 blood and 122 brain genes shared between the two conditions, revealing neuronal, immune, metabolic, and calcium-related mechanisms, with several genes as targets for existing drugs. These findings exhibit shared risk loci and genes are involved in tissue-specific mechanisms.
