Ethyl 7-Acetyl-8a-methyl-3-(1-phenyl-1H-tetrazol-5-yl)-1,4,4a,5,6,8a-hexahydro-7H-pyrano[2,3-c]pyridazine-1-carboxylate

• Autor(es): Lopes, Susana M. M. ; Lemos, Americo ; Paixão, José A. ; Pinho e Melo, Teresa M. V. D.
• Data: 2022
• Identificador Persistente: http://hdl.handle.net/10400.1/17725
• Origem: Sapientia - Universidade do Algarve
• Assunto(s): Tetrazoles; Diaza-1,3-butadiene; Pyrano[2,3-c]pyridazine; Methyl vinyl ketone dimer; Diels-alder reactions; X-ray structure
• Tipo de Documento: Artigo científico
• Idioma: Inglês
• Contribuidor(es): Sapientia

Descrição

The Diels–Alder reaction of ethyl 3-(1-phenyl-1H-tetrazol-5-yl-1,2-diaza-1,3-butadiene-1-carboxylate with 2-acetyl-6-methyl-2,3-dihydro-4H-pyran (methyl vinyl ketone dimer) regioselectively afforded the corresponding 3-(tetrazol-5-yl)-hexahydro-7H-pyrano[2,3-c]pyridazine in quantitative yield. An X-ray crystal structure of this cycloadduct is reported.