Possible role of mycotoxins, malnutrition and MECP2 dysregulation in nodding syndrome

• Autor(es): Catamo Vaz, Deise Haua da Silva ; Costa, Maria Helena da ; Buque, Helena Agostinho ; Nzwalo, Hipólito
• Data: 2024
• Identificador Persistente: http://hdl.handle.net/10400.1/26117
• Origem: Sapientia - Universidade do Algarve
• Assunto(s): MECP2; Nodding syndrome; Mycotoxins; Mozambique
• Tipo de Documento: Carta ao editor
• Idioma: Inglês
• Contribuidor(es): Sapientia

Descrição

We read with great interest the manuscript by Spencer et al. [1] suggesting a possible role of Methyl-CpG-binding protein 2 (MECP2) dysregulation in the pathogenesis of Nodding syndrome (NS), a childhood onset epileptic disorder occurring exclusively in sub-Saharan Africa. The sociodemographic and phenotypic overlap of NS with MECP2 duplication syndrome, namely the age of onset interval, female predominance;