Author(s): Lopes,Michelle Remião Ugolini ; Danowski,Adriana ; Funke,Andreas ; Rêgo,Jozelia ; Levy,Roger ; Andrade,Danieli Castro Oliveira de
Date: 2017
Origin: Oasisbr
Subject(s): antiphospholipid syndrome; anticoagulants; thrombosis
Document details
Update on antiphospholipid antibody syndrome
Description
Summary Antiphospholipid syndrome (APS) is an autoimmune disease characterized by antiphospholipid antibodies (aPL) associated with thrombosis and/or pregnancy morbidity. Most APS events are directly related to thrombotic events, which may affect small, medium or large vessels. Other clinical features like thrombocytopenia, nephropathy, cardiac valve disease, cognitive dysfunction and skin ulcers (called non-criteria manifestations) add significant morbidity to this syndrome and represent clinical situations that are challenging. APS was initially described in patients with systemic lupus erythematosus (SLE) but it can occur in patients without any other autoimmune disease. Despite the autoimmune nature of this syndrome, APS treatment is still based on anticoagulation and antiplatelet therapy.
Document Type
Journal article
Language English
Language English
