Case for diagnosis. A pruritic eruption of keratotic papules over the face and neck,

• Autor(es): Relvas,Maria ; Calvão,Joana ; Coutinho,Inês ; Cardoso,José Carlos
• Data: 2021
• Origem: Oasisbr
• Assunto(s): Acitretin; Grzybowski; Keratoacanthoma
• Tipo de Documento: Relatório
• Idioma: Inglês

Descrição

Abstract Generalized eruptive keratoacanthoma of Grzybowski is a rare variant of multiple keratoacanthomas counting with about 40 cases reported. It is a chronic and progressive disease for which none of the described therapeutic options has been entirely satisfactory. We report a case of an 83-year-old female who presented with a 3-month history of extremely pruritic, multiple, skin-coloured to erythematous to brownish, millimetric papules, with a keratotic centre. Histological examination of an incisional biopsy was consistent with the diagnosis of keratoacanthoma. The patient started acitretin 25 milligrams daily with a complete resolution of pruritus and regression of numerous lesions.