Cross-allergy between penicillins and cephalosporins: a paradigm shift

• Autor(es): Dias,Liliana ; Pedrosa,Cláudia
• Data: 2022
• Origem: SciELO Portugal
• Assunto(s): cephalosporin; cross-reactivity; penicillin; side chain
• Tipo de Documento: Artigo científico
• Idioma: Inglês

Descrição

Abstract Allergic reactions to beta-lactam antibiotics are the most common cause of allergic drug reactions. The incorrect diagnosis prevents patients from receiving a highly effective therapy. The potential cross-reactivity between penicillin and cephalosporin has very significant therapeutic implications. Penicillins and cephalosporins share a common beta-lactam ring and side chains. A number of studies indicate that the R1 side chain, rather than the ring itself, is the determining factor for cross-reactivity. Herein is presented a review of the immunologic mechanisms implicated in penicillin and cephalosporin cross-reactivity and a practical approach to the use of cephalosporins in patients allergic to penicillin.