Author(s):
Rosa, Regis Goulart ; Robinson, Caroline Cabral ; Veiga, Viviane Cordeiro ; Cavalcanti, Alexandre Biasi ; Azevedo, Luciano César Pontes de ; Machado, Flávia Ribeiro ; Berwanger, Otavio ; Avezum, Álvaro ; Lopes, Renato Delascio ; Lisboa, Thiago ; Teixeira, Cassiano ; Zampieri, Fernando Godinho ; Tomazini, Bruno Martins ; Kawano-Dourado, Letícia ; Schneider, Daniel ; Souza, Denise de ; Santos, Rosa da Rosa Minho dos ; Silva, Sabrina Souza da ; Trott, Geraldine ; Gimenes, Bruna dos Passos ; Souza, Ana Paula de ; Barroso, Bruna Machado ; Costa, Lauren Sezerá ; Brognoli, Liége Gregoletto ; Pelliccioli, Melissa Pezzetti ; Studier, Nicole dos Santos ; Schardosim, Raíne Fogliati de Carli ; Haubert, Tainá Aparecida ; Pallaoro, Victoria Emanuele Lobo ; Oliveira, Debora Mariani de ; Velho, Pedro Isaacsson ; Medeiros, Gregory Saraiva ; Gazzana, Marcelo Basso ; Zavascki, Alexandre Prehn ; Pitrez, Paulo Márcio ; Oliveira, Roselaine Pinheiro de ; Polanczyk, Carisi Anne ; Nasi, Luiz Antônio ; Hammes, Luciano Serpa ; Falavigna, Maicon
Date: 2021
Persistent ID: http://hdl.handle.net/11690/1902
Origin: Oasisbr
Subject(s): COVID-19; SARS-CoV-2; Quality of life; Patient-reported outcome measures
Description
Submitted by DSpace Unilasalle (dspace@unilasalle.edu.br) on 2021-07-30T18:05:34Z No. of bitstreams: 1 Quality of life and long-term_RBTI.pdf: 166504 bytes, checksum: 63103be1553e0b32010c4bbaa6c815ea (MD5)
Made available in DSpace on 2021-07-30T18:05:34Z (GMT). No. of bitstreams: 1 Quality of life and long-term_RBTI.pdf: 166504 bytes, checksum: 63103be1553e0b32010c4bbaa6c815ea (MD5) Previous issue date: 2021
Introduction: The long-term effects caused by COVID-19 are unknown. The present study aims to assess factors associated with health-related quality of life and long-term outcomes among survivors of hospitalization for COVID-19 in Brazil. Methods: This is a multicenter prospective cohort study nested in five randomized clinical trials designed to assess the effects of specific COVID-19 treatments in over 50 centers in Brazil. Adult survivors of hospitalization due to proven or suspected SARS-CoV-2 infection will be followed-up for a period of 1 year by means of structured telephone interviews. The primary outcome is the 1-year utility score of health-related quality of life assessed by the EuroQol-5D3L. Secondary outcomes include all-cause mortality, major cardiovascular events, rehospitalizations, return to work or study, physical functional status assessed by the Lawton-Brody Instrumental Activities of Daily Living, dyspnea assessed by the modified Medical Research Council dyspnea scale, need for long-term ventilatory support, symptoms of anxiety and depression assessed by the Hospital Anxiety and Depression Scale, symptoms of posttraumatic stress disorder assessed by the Impact of Event Scale-Revised, and self-rated health assessed by the EuroQol-5D3L Visual Analog Scale. Generalized estimated equations will be performed to test the association between five sets of variables (1- demographic characteristics, 2- premorbid state of health, 3- characteristics of acute illness, 4- specific COVID-19 treatments received, and 5- time-updated postdischarge variables) and outcomes. Ethics and dissemination: The study protocol was approved by the Research Ethics Committee of all participant institutions. The results will be disseminated through conferences and peer-reviewed journals.
