Author(s): Sousa, Antonio H. ; Silva Junior, José N. ; Guedes, Maria L. S. ; Braz-Filho, Raimundo ; Costa-Lotufo, Letícia V. ; Araújo, Ana J. ; Silveira, Edilberto R. ; Lima, Mary A. S.
Date: 2016
Origin: Oasisbr
Subject(s): Diterpenos; Diterpenes
Document details
New terpenoids from Croton limae (Euphorbiaceae)
Description
An asymmetrical dimer of kaurane diterpene and monoterpene and four novel diterpenes were isolated from the roots of Croton limae, along with kaempferol-3-O-glucoside, ombuin- 3-O-rutinoside and acetyl aleuritolic acid. The cytotoxic activity of the kaurane diterpene was evaluated against colorectal adenocarcinoma (HCT-116), ovarian carcinoma (OVCAR-8) and glioma (SF-295) cell lines, exhibiting IC50 values of 7.14, 8.19 and > 10 µg mL−1, respectively.
Document Type
Journal article
Language English
Language English
