Autor(es): Roomruangwong, Chutima ; Barbosa, Decio Sabbatini ; Matsumoto, Andressa Keiko ; Nogueira, André de Souza ; Kanchanatawan, Buranee ; Sirivichayakul, Sunee ; Carvalho, André Ferrer ; Duleu, Sebastien ; Geffard, Michel ; Moreira, Estefania Gastaldello ; Maes, Michael
Data: 2017
Origem: Oasisbr
Assunto(s): Depression; Inflammation; Complexo Antígeno-Anticorpo (Immune)
Objectives: To examine oxidative & nitrosative stress (O & NS) biomarkers at the end of term in relation to perinatal affective symptoms, neuro-immune biomarkers and pregnancy-related outcome variables. Methods: We measured plasma advanced oxidation protein products (AOPP), nitric oxide metabolites (NOx), total radical trapping antioxidant parameter (TRAP), -sulfhydryl (-SH), peroxides (LOOH) and paraoxonase (PON)1 activity in pregnant women with and without prenatal depression and non-pregnant controls. Results: Pregnancy is accompanied by significantly increased AOPP and NOx, and lowered TRAP, -SH and LOOH. Increased O & NS and lowered LOOH and -SH levels are associated with prenatal depressive and physiosomatic symptoms (fatigue, pain, dyspepsia, gastro-intestinal symptoms). Increased AOPP and NOx are significantly associated with lowered –SH, TRAP and zinc, and with increased haptoglobin and C-reactive protein levels. Increased O & NS and lowered TRAP and PON 1 activity, at the end of term predict mother (e.g. hyperpigmentation, labor duration, caesarian section, cord length, breast milk flow) and baby (e.g. sleep and feeding problems) outcome characteristics. Conclusions: Pregnancy is accompanied by interrelated signs of O & NS, lowered antioxidant defenses and activated neuro-immune pathways. Increased O & NS at the end of term is associated with perinatal depressive and physio-somatic symptoms and may predict obstetric and behavioral complications in mother and baby.
