Author(s): Lopes, Synara Cavalcante ; Gadelha, Daniel Duarte ; Carvalho, Manuela Dias de ; Fernandes, Virgínia Oliveira ; Montenegro Junior, Renan Magalhães
Date: 2019
Origin: Oasisbr
Subject(s): Vitamina B12; Deficiência de Vitamina B1; Ácido Metilmalónico; Doenças Metabólicas; Síndrome Metabólica; Diabetes
Vitamin B12 is a water-soluble essential micronutrient, required by all the body cells. Its deficiency has been implicated not only in hematological and neurological disorders, but also in many metabolic processes, such as insulin resistance and body composition changes, which have aroused particular interest in recent years. This study reviews the physiology of vitamin B12 from its digestion and absorption to its distribution in tissues, metabolic effects and controversies regarding the diagnosis of deficiency, and to dietary and pharmacological treatments.
