Autor(es): Silva, Isabelle Souza de Mélo ; Santos, Raíssa Fernanda Evangelista Pires dos ; Melo, Thiane de Vasconcellos Costa ; Silva, Ana Jéssica Cassimiro da ; Sarmento, Patrícia de Albuquerque ; Lúcio, Ingrid Martins Leite ; Campesatto, Eliane Aparecida ; Padilha, Francine Ferreira ; Conserva, Lucia Maria ; Bastos, Maria Lysete de Assis
Data: 2014
Origem: Oasisbr
Assunto(s): Euphorbiaceae; Testes de Sensibilidade Microbiana; Sobrevivência Celular
Medicinal plants with antimicrobial properties built into the problem of infection have been investigated, guide the discovery of efficient against the emerging pathogens herbal related to bacterial and fungal infection. This study aimed to enlarge the possibilities of knowledge about antibacterial and antifungal activities of this plant, in the treatment of infections. The results of antimicrobial activity and cytotoxicity of two fractions in MeOH/H2O from ethanol and acetone extracts of guanxuma-of-Horn [Sebastiania corniculata (Vahl) Mull. Arg.] (Euphorbiaceae) evaluated the extracts by disk diffusion test (DD) and the method of the Minimum Inhibitory Concentration (MIC). The extracts were active for Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus pneumoniae, Pseudomonas aeruginosa, Acinectobacter calcoaceticus and Proteus mirabilis in the DD test. However, the best results for these fractions were against P. aeruginosa with an MIC from 250 to 125 μg/mL, respectively. In the evaluation of cytotoxic for cell viability by MTT, only a dose of 100 μg/mL exhibited moderate cytotoxicity with p < 0.0001. In this perspective, the other extracts showed significant cytotoxicity, which suggests further research to evaluate the anti-tumor activity and consolidate the evidence obtained in the research present.
