Autor(es): Nunes, Geandra B. L. ; Policarpo, Paola R. ; Costa, Luciana M. ; Silva, Teresinha G. da ; Militão, Gardenia Carmen G. ; Câmara, Celso A. ; Barbosa Filho, José Maria ; Gutierrez, Stanley Juan C. ; Islam, Mohammed T. ; Freitas, Rivelilson M. de
Data: 2014
Origem: Oasisbr
Assunto(s): Plantas Medicinais; Indústria Farmacêutica
This study aimed to study the in vitro antioxidant activity and cytotoxicity on tumor cells lines of six synthetic substances derived from riparins. All the substances showed antioxidant activity and riparins C, D, E, F presented cell growth inhibition rates greater than 70%, suggesting that these molecules have antitumor properties. These substances also caused greater than 80% releases of cytoplasmic lactate dehydrogenase enzyme (LDH). Although the antioxidant and antitumor properties presented herein require further assessment, the outcomes indicate that these novel riparins are promising biologically active compounds.
