Project/scholarship details

Parkinson’s Disease (PD) is one of the major neurodegenerative disorders, characterized by massive loss of dopaminergic neurons, leading to severe motor impairment. DJ-1 was identified as a causative gene of familial early onset PD, later confirmed in animal models. Although the physiological functions of DJ-1 are not fully understood, several lines of evidence suggest that it is involved in protection against oxidative stress, the proposed cause of death of dopaminergic neurons in PD. The mechanism responsible for DJ-1-mediated neuronal rescue was thought to be direct scavenging of reactive oxygen species (ROS), however, recent data suggests that activation of survival and repression of stress- and apoptosis-related signaling pathways play the most significant role. Additional studies identified direct binding of DJ-1 to several proteins, modulating their activity (ASK-1, alfa-Synuclein, TH and L-DOPA Decarboxilase). By extensively studying DJ-1 functions, new perspectives will be opened for PD. As a result, future work may concentrate on the design of small molecules that may easily cross the blood-brain barrier and compensate for the loss of DJ-1 in patients, by artificially modulating the relevant signaling pathways identified.

  • Funder

    FCT - Fundação para a Ciência e a Tecnologia, I.P.

  • Funder's country

    Portugal

  • Funding program

    5876-PPCDTI

  • Funding amount

    172,670.00 €

  • Start date

    2013-05-01

  • End date

    2015-09-30

Documents

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DJ‐1 neuronal rescue under oxidative stress: implications for Parkinson's disease

Anjo, Sandra Isabel dos Santos

Tese de doutoramento em Biociências, na especialidade de Biologia Celular e Molecular, apresentada ao Departamento de Ciências da Vida da Faculdade de Ciências e Tecnologia da Universidade de Coimbra; Mutações em vários genes, incluindo o gene DJ-1, têm sido referidas como causadores de formas hereditárias da Doença de Parkinson (DP), sendo que a partir do estudo das proteínas codificadas por esses genes já for...

Date: 2017   |   Origin: Estudo Geral - Universidade de Coimbra
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Oxidative Stress Biomarkers: Closer to early diagnosis of neurodegenerative dis...

Salvado, Ruben Joel Bispo

Dissertação de Mestrado em Química Forense apresentada à Faculdade de Ciências e Tecnologia; Parkinson’s disease (PD) is a neurodegenerative disorder, the second most common after Alzheimer’s disease, and the most common age-associated movement disorder, affecting 1% of the population over 60 years old. The cause of the disease is not yet known, but some of the factors that contribute for its appearance can be ...

Date: 2017   |   Origin: Estudo Geral - Universidade de Coimbra
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Development and validation of an analytical method for quantification of dopami...

Dias, Ana Sofia Abrantes

Dissertação de Mestrado em Química Forense apresentada à Faculdade de Ciências e Tecnologia; A doença de Parkinson (DP) é a segunda doença neurodegenerativa mais comum, afetando mais de 6 milhões de pessoas em todo o mundo. Trata-se de um distúrbio neurodegenerativo progressivo caracterizado, neuropatologicamente, por uma perda de neurónios dopaminérgicos numa região específica do cérebro, nomeadamente a substâ...

Date: 2017   |   Origin: Estudo Geral - Universidade de Coimbra
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