Project/scholarship details
- Project/scholarship ID
122400
- Reference
PTDC/SAU-EPI/122400/2010
- FundRef URI
- Funder
FCT - Fundação para a Ciência e a Tecnologia, I.P.
- Funder's country
Portugal
- Funding program
3599-PPCDT
- Funding amount
199,011.00 €
- Start date
2012-03-21
- End date
2015-09-30
Documents
Evolution of the human immunodeficiency virus type 2 envelope in the first year...
Rocha, Cheila; Calado, Rita; Borrego, Pedro; Marcelino, José Maria; Bártolo, Inês; Rosado, Lino; Cavaco-Silva, Patrícia; Perpétua, Gomes"Background: Differently from HIV-1, HIV-2 disease progression usually takes decades without antiretroviral therapy and the majority of HIV-2 infected individuals survive as elite controllers with normal CD4+ T cell counts and low or undetectable plasma viral load. Neutralizing antibodies (Nabs) are thought to play a central role in HIV-2 evolution and pathogenesis. However, the dynamic of the Nab response and ...
Drug resistance and genetic diversity of Mycobacterium tuberculosis in Luanda, ...
Perdigão, João; Clemente, Sofia; Ramos, Jorge; Masakidi, Pedro; Machado, Diana; Silva, Carla; Couto, Isabel; Viveiros, Miguel; Taveira, NunoPoster presented at the 36th Annual Congress of the European Society of Mycobacteriology. Riga, Latvia, 28 June - 1 July 2015; "Sub-saharan Africa contributes heavily to the tuberculosis (TB) burden worldwide. According to the World Health Organization (WHO), Africa exhibits the highest TB regional incidence rate (280 cases per 100 000 habitants) and the highest Human Immunodeficiency Virus co-infection rate (3...
Entry inhibitors and Carbosilane dendrimers are potent inhibitors of cell-assoc...
Diniz, A. R.; Briz, V.; Borrego, P.; Palladino, C.; Rodés, C.; De la Mata, F. J.; Gómez, R.; Muñoz-Fernández, M. A.; Taveira, N.Poster presented at the 2015 Keystone Symposia Conference X5: HIV Vaccines. Banff, Alberta, Canada, 22-27 March 2015; "Pre-exposure prophylaxis with topical microbicides formulated with antiviral agents can prevent HIV-1 acquisition. The ideal microbicide should prevent both cell-free and cell-associated HIV-1 and HIV-2 infections in the vaginal or rectum mucosa. So far, few candidate microbicides have been tes...
Envelope C2-V3-C3-specific antibodies from HIV-1 infected patients from Angola ...
Calado, R.; Duarte, J.; Diniz, A. R.; Borrego, P.; Marcelino, J. M.; Wilton, J.; Bartólo, I.; Clemente, S.; Taveira, N.Poster presented at the 2015 Keystone Symposia Conference X5: HIV Vaccines. Banff, Alberta, Canada, 22-27 March 2015; "Development of immunogens that induce broadly neutralizing antibodies (bNAbs) is a major goal in HIV-1 vaccine field. Recently, we found that bNAbs can be elicited in Balb/c mice against HIV-2 by using a prime-boost vaccination strategy combining recombinant Vaccinia virus expressing a truncate...
The contribution of Angola to the early spread of the HIV-1 epidemic
Pineda-Peña, Andrea-Clemencia; Varanda, Jorge; Theys, Kristof; Bártolo, Inês; Leitner, Thomas; Taveira, Nuno; Vandamme, Anne-Mieke; Abecasis, Ana B.Poster presented at the 22nd International HIV Dynamics and Evolution. Budapest, Hungary, 13-16 May 2015; "Understanding how, when and why the HIV-1 virus adapted to the human population and become pandemic is crucial to prevent its propagation and the establishment of other potential future viral pandemics. It is known that the HIV-1 group M epidemic started in Kinshasa, Democratic Republic of Congo (DRC), and...
Evaluation of an in-house molecular HIV-1 test to assess mother-to-child HIV-1 ...
Martin, F.; Palladino, C.; Mateus, R.; Clemente, S.; Gomes, P.; Taveira, N.Poster presented at the 17th Annual International Meeting of the Institute of Human Virology. Baltimore, 27-30 September 2015; "Mother-to-child-transmission (MTCT) rate has decreased sharply in recent years in most of the sub-Saharan Africa, however 220,000 children acquired HIV-1 in 2014. PCR detection of proviral DNA is the most sensitive method for early infant diagnosis (EID) of HIV-1 infection. Commercial ...
Inhibition of HIV cell-to-cell fusion by antiretroviral drugs and neutralizing ...
Diniz, A. R.; Borrego, P.; Bártolo, I.; Taveira, N.Poster presented at the 7th iMed.ULisboa Postgraduate Students Meeting. Lisbon, 15 July 2015; "Inhibition of HIV cell entry by antiretroviral drugs and neutralizing antibodies (NAbs) is typically measured in assays where cell-free virions enter reporter cell lines. However, direct Env-mediated cell-to-cell transmission is a major mechanism of HIV infection that also needs to be targeted. In this work we aimed t...
Rare HIV-1 subtype J genomes and a new H/U/CRF02_AG recombinant genome suggests...
Bártolo, Inês; Calado, Rita; Borrego, Pedro; Thomas, Leitner; Taveira, NunoThis is the author’s version of a work that was accepted for publication in AIDS Research and Human Retroviruses .; Final publication is available from Mary Ann Liebert, Inc., publishers http://dx.doi.org/10.1089/aid.2016.0084; "Angola has an extremely diverse HIV-1 epidemic fueled in part by the frequent interchange of people with the Democratic Republic of Congo (DRC) and Republic of Congo (RC). Characterizat...
Development of synthetic light-chain antibodies as novel and potent HIV fusion ...
Cunha-Santos, Catarina; Figueira, Tiago N.; Borrego, Pedro; Oliveira, Soraia S.; Rocha, Cheila; Couto, Andreia; Cantante, Cátia; Santos- Costa, QuirinaThis is a non-final version of an article published in final form in AIDS. 2016 Jul 17;30(11):1691-701.; "Objective: To develop a novel and potent fusion inhibitor of HIV infection based on a rational strategy for synthetic antibody library construction. Design: The reduced molecular weight of single-domain antibodies (sdAbs) allows targeting of cryptic epitopes, the most conserved and critical ones in the cont...
Genetic diversity, transmission dynamics and drug resistance of Mycobacterium t...
Perdigão, João; Clemente, Sofia; Ramos, Jorge; Masakidi, Pedro; Machado, Diana; Silva, Carla; Couto, Isabel; Viveiros, Miguel; Taveira, NunoThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a co...
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