Project/scholarship details

  • Funder

    FCT - Fundação para a Ciência e a Tecnologia, I.P.

  • Funder's country


  • Funding program


  • Funding amount

    338,852.00 €

  • Start date


  • End date



Design of bio-based supramolecular structures through self-assembly of α-lactal...

Monteiro, Adenilson A.; Monteiro, Marcia R.; Pereira, Ricardo N.; Diniz, Renata; Costa, Angélica R.; Malcata, F. Xavier; Teixeira, J. A.

Bovine α-lactalbumin (α-La) and lysozyme (Lys), two globular proteins with highly homologous tertiary structures and opposite isoelectric points, were used to produce bio-based supramolecular structures under various pH values (3, 7 and 11), temperatures (25, 50 and 75 °C) and times (15, 25 and 35 min) of heating. Isothermal titration calorimetry experiments showed protein interactions and demonstrated that str...

Candida tropicalis biofilm and human epithelium invasion is highly influenced b...

Ferreira, C.; Gonçalves, Bruna; Boas, Diana Patrícia Andrade Vilas; Oliveira, Hugo; Henriques, Mariana; Azeredo, Joana; Silva, Sónia Carina

Objective: The main goal of this study was to investigate the role of pH on Candida tropicalis virulence determinants, namely the ability to form biofilms and to colonize/invade reconstituted human vaginal epithelia. Methods: Biofilm formation was evaluated by enumeration of cultivable cells, total biomass quantification and structural analysis by scanning electron microscopy and confocal laser scanning microsc...

Antibacterial properties of multifunctional coatings Ag-ZrCN for biomedical dev...

Silva, Isabel Maria Ferreri de Gusmão e

Nowadays, with the increase of elderly population and related health problems, knee and hip joint prosthesis are being widely used worldwide. However, failure of these invasive devices is still a concern in the medical field thus demanding the revision of the surgical procedure. Within the reasons of failure are wear fatigue and microbial infections ( Staphylococcus epidermidis has emerged as one of the major n...

The influence of the medium composition on the biosurfactants produced by Lacto...

Vecino, Xanel; Rodríguez-López, L.; Cruz, J. M.; Moldes, A. B.; Rodrigues, L. R.

[Excerpt] Lactic acid bacteria is an interesting group of microorganisms for the production of biosurfactants. In addition, these bacteria are generally recognized as safe by the American Food and Drug Administration. An example is the Lactobacil/us paracasei that was isolated from a Portuguese dairy industry and has been previously reported by Gudina and collaborators [1] forthe production of biosurfactants.Th...

Chapter 18 - Gliadins in foods and the electronic tongue

Veloso, Ana C. A.; Dias, Luís G.; Rodrigues, L. R.; Peres, António M.

The commercialization of safe foods is a main concern and should be ensured throughout the entire food supply chain. So, fast, sensitive, and reliable analytical methods are needed to identify food-related specific hazards, ensuring consumers protection and avoiding health problems. This chapter is focused on the emerging (bio)sensors to detect the heat-stable allergen gliadin in gluten-free foods. A brief over...

Staphylococcus epidermidis biofilm-released cells induce a prompt and more mark...

França, Ângela Maria Oliveira Sousa; Pérez-Cabezas, Begoña; Correia, Alexandra; Pier, G. B.; Cerca, Nuno; Vilanova, Manuel

Staphylococcus epidermidis biofilm formation on indwelling medical devices is frequently associated with the development of chronic infections. Nevertheless, it has been suggested that cells released from these biofilms may induce severe acute infections with bacteraemia as one of its major associated clinical manifestations. However, how biofilm-released cells interact with the host remains unclear. Here, usin...

In vitro anti-Candida activity of Glycyrrhiza glabra L.

Martins, Natália; Ferreira, Isabel C.F.R.; Henriques, Mariana; Silva, Sónia

The severity and frequency of opportunistic fungal infections still growing, concomitantly to the increasing rates of antimicrobial drug’s resistance. Natural matrices have been used over years due to its multitude of health benefits, including antifungal potential. Thus, the present work aims to evaluate the anti-Candida potential of the phenolic extract and individual phenolic compounds of Glycyrrhiza glabra ...

Date: 2016   |   Origin: Biblioteca Digital do IPB

Fructo-oligosaccharides: production, characterization and purification

Gonçalves, Clarisse Salomé Nobre; Teixeira, J. A.; Rodrigues, L. R.

The consumers interest in healthy and high nutritional food has significantly increased in the recent years. This trend towards the adoption of healthier lifestyles has been the main driver for the great demand of functional ingredients, such as the prebiotics fructo-oligosaccharides (FOS). Industrially, FOS are produced from sucrose through purified enzymes, in two-step bioprocesses, with low theoretical yield...

Antimicrobial peptide combinations against major infectious pathogens: in vitro...

Jorge, Paula Alexandra Silva

Microbiology research has been investing significant efforts in the development of new and effective antimicrobial therapies against the growing number of multiresistant pathogens. Notably, the use of natural compounds, such as antimicrobial peptides (AMP), and the combination of different antimicrobials are being increasingly explored as means to improve individual agent actions while minimising microorganism ...

Management and mitigation strategies for mycotoxins: the biological solutions

Abrunhosa, Luís

Mycotoxins are toxic secondary metabolites produced by fungi that are found worldwide in many food products. They are a diverse group of chemical compounds that possess a multiplicity of toxic properties and affect human and farm animal health. Additionally, they cause significant economic losses. The problem of mycotoxins results mainly from fungal growth on crop cultures at the pre - or post - harvest stages....


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