Plant-based dairy alternatives (PBDA) represent a significant portion of the consumption of plant-based products, mainly to replace or complement the diet in relation to dairy milk, due to their health properties, the absence of lactose, environmental impacts, and consumer preference. These products have attracted a wide range of consumers, as they can be derived from different plant sources such as soy, rice, ...
Powdered foods are easy to store and transport, with a longer shelf life that minimizes potential waste, contributing to sustainable development. Each food category has a unique composition, responsible for its chemical and physical attributes, which directly influences the stability of powdered products. The drying method used is essential to obtain the desired characteristics of the powdered food, and the cho...
KRAS mutations are one of the most frequent oncogenic mutations of all human cancers, being more prevalent in pancreatic, colorectal, and lung cancers. Intensive efforts have been encouraged in order to understand the effect of KRAS mutations, not only on tumor cells but also on the dynamic network composed by the tumor microenvironment (TME). The relevance of the TME in cancer biology has been increasing due t...
KRAS, one of the RAS protein family members, plays an important role in autophagy and apoptosis, through the regulation of several downstream effectors. In cancer cells, KRAS mutations confer the constitutive activation of this oncogene, stimulating cell proliferation, inducing autophagy, suppressing apoptosis, altering cell metabolism, changing cell motility and invasion and modulating the tumor microenvironme...
Muitos são os temas de estudo que unem o jurista italiano ao português, visto que comparativamente ambos se exprimem numa língua historicamente determinada e regulamentada por rígidas normas jurídicas. Contudo, a estreita relação entre língua e sistema jurídico não implica apenas a passagem de uma língua para outra, mas de um sistema normativo para outro (de Groot & Hoeks, 1995, p. 18), e os conceitos relaciona...
Introduction: Vitamin D deficiency has been linked to increased susceptibility to the development of rheumatoid arthritis and with disease activity. The objective of this studywas to evaluate vitamin D status in patients with RA and toassess the relationship between vitamin D levels and pain.Methods: In a cohort of 45 patients with RA, 25-hydroxyvitamin D3 [25(OH)D3] levels, parathyroid hormone, C-reactiveprote...
The antioxidant activity and individual bioactive compounds of lettuce, cultivated with 2.5–30% (v/v) of fresh or composted espresso spent coffee grounds, were assessed. A progressive enhancement of lettuce’s antioxidant capacity, evaluated by radical scavenging effect and reducing power, was exhibited with the increment of fresh spent coffee amounts, while this pattern was not so clear with composted treatment...
No presente trabalho aplicou-se um desenho fatorial a 2 níveis para determinar o efeito de algumas condições operacionais a usar na extração de compostos com atividade antioxidante da alface, sua importância e possíveis interações. De entre os fatores a analisar estudaram-se a temperatura de extração (30 e 60 ºC), o tipo de solvente (metanol e água), o tempo de extração (10 e 30 minutos), o tipo de amostra (des...
O café é um dos produtos agrícolas de maior importância no comércio mundial, sendo maioritariamente produzido nas regiões tropicais e consumido, principalmente, na Europa e Estados Unidos da América. Ao consumo elevado de café encontra-se associado a produção de resíduos de baixo valor. A reutilização de resíduos do café tem sido uma das prioridades dos países produtores, tanto por razões ecológicas como económ...
The main objective of the present work was to optimize the extraction conditions for simultaneous maximization of total reducing (TRC) and antioxidant (AC) capacities for lettuce (Lactuca sativa L.) by-products extracts, using response surface methodology. For this, a design of experiments (DOE) with different combinations of solvents (water, methanol and acetone) extraction temperatures (30–60 ◦C) and time (10...