4 documents found, page 1 of 1
What would I Change in the Service to Improve Training
Fonseca Oliveira, João; Matos Costa, João; Jorge Casimiro, Hugo; Ferreira, Teresa; Martins Baptista, António; Santos, Lèlita
Kounis Syndrome: A Rare Case of Omeprazol Anaphylaxis
Alves Pinto, Maria João; Manata, José Pedro; Almeida, Raquel; Matos Costa, JoãoAnaphylaxis is an acute hypersensitivity reaction, potentially fatal. Omeprazole has revolutionized the treatment of pathologies related to acid hypersecretion. There are a few case reports of anaphylactic reactions due to proton pump inhibitors (PPI). We present a case of a 30-year-old woman, with acute gastroenteritis, who received intravenous (IV) omeprazole, and immediately experienced intensive retrosterna...
PROS1 novel splice site variant decreases protein S expression in patients from...
Menezes, Juliane; Ventura, Célia; Matos Costa, João; Parreira, Elsa; Romão, Luísa; Gonçalves, JoãoProtein S (PS) is a widely studied protein with an important function in the downregulation of thrombin formation. Since its discovery in 1976, more than 400 variants have been described in PS gene (PROS1) associated with PS deficiency and as a risk factor for venous thromboembolism (VTE). We describe a novel variant, c.1871-14T>G, in intron 14 of PROS1 gene identified in two patients with PS deficiency from tw...
Diagnosis of coeliac sprue in adulthood
Matos Costa, João; Santos, Maria Cristina; Carrilho, Fernanda; Gameiro, Ana; Garcia, Helena; Rodrigues, NelsonConcepts about diagnosis of coeliac sprue have been changing in the past decade,namely recognising non-classical types of this disease, usually diagnosed in childhood. The development of serological tests with high specificity and sensitivity has lead to increased diagnosis of atypical or assymptomatic types, with consequent increase in incidence and prevalence of coeliac sprue.We report the case of a 25-year o...