13 documents found, page 1 of 2

A Case of Acute Interstitial Nephritis After Two Doses of the BNT162b2 SARS-CoV...

The development of vaccines to prevent COVID-19 breakouts came with highly positive results but some unexpected side effects. Rare side effects have been seen with the BNT162b2 SARS-CoV 2 vaccine. Case Presentation: We present the case of a 45-year-old female patient who developed an acute kidney injury needing urgent hemodialysis one week after the second administration of the BNT162b2 SARS-CoV 2 vaccine. She ...

Biomarkers and genetic modulators of cerebral vasculopathy in sub-Saharan ances...

We investigated biomarkers and genetic modulators of the cerebral vasculopathy (CV) subphenotype in pediatric sickle cell anemia (SCA) patients of sub-Saharan African ancestry. We found that one VCAM1 promoter haplotype (haplotype 7) and VCAM1 single nucleotide variant rs1409419_T were associated with stroke events, stroke risk, as measured by time-averaged mean of maximum velocity in the middle cerebral artery...

Biomarkers and genetic modulators of cerebral vasculopathy in sub-Saharan ances...

We investigated biomarkers and genetic modulators of the cerebral vasculopathy (CV) subphenotype in pediatric sickle cell anemia (SCA) patients of sub-Saharan African ancestry. We found that one VCAM1 promoter haplotype (haplotype 7) and VCAM1 single nucleotide variant rs1409419_T were associated with stroke events, stroke risk, as measured by time-averaged mean of maximum velocity in the middle cerebral artery...

Genetic modulators of fetal hemoglobin expression and ischemic stroke occurrenc...

Sickle cell anemia (SCA) is an autosomal recessive monogenic disease with significant clinical variability. Cerebrovascular disease, particularly ischemic stroke, is one of the most severe complications of SCA in children. This study aimed to investigate the influence of genetic variants on the levels of fetal hemoglobin (Hb F) and biochemical parameters related with chronic hemolysis, as well as on ischemic st...

Maize open-pollinated populations physiological improvement: validating tools f...

Participatory selection—exploiting specific adaptation traits to target environments—helps to guarantees yield stability in a changing climate, in particular under low-input or organic production. The purpose of the present study was to identify reliable, low-cost, fast and easy-to-use tools to complement traditional selection for an e ective participatory improvement of maize populations for drought resistance...

Genetic modulators of fetal hemoglobin expression and ischemic stroke occurrenc...

Sickle cell anemia (SCA) is an autosomal recessive monogenic disease with significant clinical variability. Cerebrovascular disease, particularly ischemic stroke, is one of the most severe complications of SCA in children. This study aimed to investigate the influence of genetic variants on the levels of fetal hemoglobin (Hb F) and biochemical parameters related with chronic hemolysis, as well as on ischemic st...

Quantificação do Produto da Força Aérea

O instinto do Homem se agrupar, tornando-se mais forte e capaz na busca de um objetivo comum, remonta aos primórdios da sua existência. Através de gerações, esta reunião de capacidades e competências individuais, sucessivamente também mais organizada, permitiu-lhe obter uma maior vantagem para o grupo. Constitui-se assim o conceito primário de Organização: duas ou mais pessoas que realizam tarefas de forma coor...

Variação genética associada ao nível de hemólise crónica na drepanocitose: um e...

Haemolysis in sickle cell anaemia: a genotype/phenotype association study

Introduction: Sickle cell anaemia (SCA) is a clinically heterogeneous autosomal recessive monogenic anaemia characterised by chronic haemolysis and recurrent episodes of severe vaso-occlusion and infection. Several environmental and genetic determinants have been suggested to modulate the onset, course and outcome of SCA. The level of chronic haemolysis has been considered a critical measure of SCA severity and...

Genetic variation in CD36, HBA, NOS3 and VCAM1 is associated with chronic haemo...

Chronic haemolysis stands out as one of the hallmarks of sickle cell anaemia, a clinically heterogeneous autosomal recessive monogenic anaemia. However, the genetic architecture of this sub-phenotype is still poorly understood. Here, we report the results of an association study between haemolysis biomarkers (serum LDH, total bilirubin and reticulocyte count) and the inheritance of 41 genetic variants of ten ca...