16 documents found, page 1 of 2

Image-guided nanodelivery of Pt(IV) prodrugs to GRP-receptor positive tumors

Over the last decades, gold nanoparticles (AuNPs) have proven to be remarkable tools for drug delivery and theranostic applications in cancer treatment. On the other hand, Pt(IV) prodrugs have been employed as an interesting alternative to the more common Pt(II) complexes, such as cisplatin, for cancer chemotherapy. Searching to design an image-guided nanocarrier to deliver selectively Pt(IV) prodrugs to tumors...

NOVA MUTAÇÃO DO GENE SDHD EM PACIENTES COM PARAGANGLIOMAS DO CORPO CAROTÍDEO

Paragangliomas (PGLs) are neuroendocrine neoplasms that can occur throughout the body wherever there is paraganglia. Representing 0.03% of all tumours, PGLs are extremely rare. Although predominantly benign and amenable to cure by surgical ressection, up to 6% can be malignant. To date, three genes have been identified that are associated with Familial PGLs. All three encode subunits (D, B and C) of the enzyme ...

Public policies of education in developing contexts perceived in the complexity...

This article wishes to assess public policies of education in Angola, carried out in cooperation procedures for post 2015 development, namely, social partnerships established between the Angolan Government and organizations of the second and third sectors in the area of adult literacy in a professional environment. References are made to some conclusions of a study carried out within a PhD in Educational Scienc...

ISCHAEMIA IN THE NEONATE–CASE REPORT

Introduction: Peripheral ischaemia and gangrene in a neonate is rare,with fewer than a hundred cases reported in the literature. Neonatal limb ischaemia present considerable challenges in diagnosis and management. The published literature is limited to case reports and case series and there are no large trials comparing different therapies. Objectives: The authors describe the case of a 4-day newborn transferre...

ACUTE LOWER LIMB ISCHEMIA: 7 YEARS OF THROMBOEMBOLECTOMIES IN THE ELDERLY

Introduction: Acute lower limb ischemia (ALLI) is a common emergency in Vascular Surgery, with significant morbidity and mortality. Despite other therapeutic options, thromboembolectomy is still a valid option. The aim of this study is to assess the safety and efficacy of this surgical option in the treatment of ALLI, in elderly patients. Methods: Retrospective, single center study covering the period between J...

Políticas públicas de educação em contextos em desenvolvimento percebidas na co...

O artigo pretende analisar políticas públicas de ensino em Angola, concretizadas em práticas de cooperação para o desenvolvimento pós-2015, nomeadamente as parcerias sociais estabelecidas entre o Estado angolano e organizações do segundo e terceiro sectores no âmbito da alfabetização de adultos em contexto profissional.São abordadas algumas conclusões de um estudo realizado a propósito de um doutoramento em Ciê...

SHORT AND LONG TERM MORTALITY RATES AFTER MAJOR LOWER LIMB AMPUTATION IN PATIEN...

Introduction: Mortality rates after lower limb amputation are notoriously high and age is associated with increased mortality. The aim of this retrospective study was to determine mortality rates after a first major lower limb amputation in a cohort of patients older 80 years old. Methods: We performed an analysis of factors affecting early and late outcome after major lower limb amputation for peripheral vascu...

IMPACT OF TYPE-II ENDOLEAK ON ANEURYSM SAC IN A SINGLE CENTER

Objective: Type 2 endoleak occurs in up to 30% of endovascular aneurysm repair (EVAR), but its long-term significance continues to be one of the most controversial topics. We reviewed our experience to evaluate late outcomes associated with type 2 endoleak. Methods: Between January 2008 to December 2014, 57 patients undergoing EVAR were enrolled in the presenting study. Computed tomography (angioCT) scan assess...

Políticas públicas de educação em contextos em desenvolvimento percebidas na co...

This communication intends to analyze public policies of education in Angola, concretized in practices of cooperation to post 2015 development, notably, the social partnerships established between the Angolan Government and organizations of the second and third sectors in the context of adult literacy in a professional environment. References are made to some conclusions of a study carried out within a PhD in E...

A complexidade do Glocal: Uma abordagem metodológica para compreender fluxos de...