24 documents found, page 1 of 3
The emerging landscape of SGLT2 inhibitors in pediatric populations with kidney...
Freitas, Joana; Machado, Sara Nogueira; Vieira, Beatriz; Monteiro, Sara; Faria, Sameiro; Costa, Teresa; Mota, ConceiçãoSodium-glucose cotransporter 2 inhibitors (SGLT2i), originally developed as innovative antihyperglycemic agents, have demonstrated significant benefits in improving metabolic markers and protecting the kidneys and heart in patients with or without type 2 diabetes mellitus. The mechanisms behind these unexpected cardiorenal benefits cannot be attributed solely to improved glycemic control. Recent data suggest th...
The emerging landscape of SGLT2 inhibitors in pediatric populations with kidney...
Freitas, Joana; Machado, Sara Nogueira; Vieira, Beatriz; Monteiro, Sara; Faria, Sameiro; Costa, Teresa; Mota, ConceiçãoSodium-glucose cotransporter 2 inhibitors (SGLT2i), originally developed as innovative antihyperglycemic agents, have demonstrated significant benefits in improving metabolic markers and protecting the kidneys and heart in patients with or without type 2 diabetes mellitus. The mechanisms behind these unexpected cardiorenal benefits cannot be attributed solely to improved glycemic control. Recent data suggest th...
Estimating the Glomerular Filtration Rate in Pediatric Patients With Neurogenic...
Menezes, Catarina; Costa, Teresa; Brás, Catarina; Sousa, Patrícia; Mendes, Ana; Amorim, Rosa; Faria, Maria Do Sameiro; Mota, ConceiçãoBackground and objective Patients with neurogenic bladder (NB) are at a higher risk of developing chronic kidney disease (CKD). Due to their lower muscle mass, the estimated glomerular filtration rate (eGFR) based on creatinine (Cr) may be overestimated and delay the diagnosis of renal failure. This study compared eGFR calculated with different equations based on Cr and/or cystatin C (CysC) in children with NB,...
Hypokalemia and hyperkalemia: Two Sides of the Same Coin
Tavares, Joana; Mosca, Sara; Faria, Maria do Sameiro; Mota, ConceiçãoIntroduction: Potassium (K+) is the main intracellular cation and is crucial for normal cellular function, especially during children’s development and growth course. Changes in the homeostatic mechanisms of potassium regulation can lead to hypokalemia or hyperkalemia. Objective: This study aimed to provide a narrative review of this common, yet complex, condition of the clinical practice. Development/Conclusio...
Imaging clinical case
Batista, Ana Rita; Valpaços, Catarina; Sousa, Pedro; Costa, Teresa; Mota, Conceição; Reis, Armando; Faria, Maria SameiroHere in is reported the case of a 16-year-old female diagnosed with vitreous haemorrhage and hemangioblastoma of the retina, referred to the Emergency Department due to sudden vision loss. Brain and pelvic magnetic resonance imaging showed cerebellar hemangioblastomas and renal nodular lesions of suspicious nature. The patient was submitted to partial left nephrectomy and histological examination revealed papil...
Imaging clinical case
Batista, Ana Rita; Valpaços, Catarina; Sousa, Pedro; Costa, Teresa; Mota, Conceição; Reis, Armando; Faria, Maria Do SameiroHere in is reported the case of a 16-year-old female diagnosed with vitreous haemorrhage and hemangioblastoma of the retina, referred to the Emergency Department due to sudden vision loss. Brain and pelvic magnetic resonance imaging showed cerebellar hemangioblastomas and renal nodular lesions of suspicious nature. The patient was submitted to partial left nephrectomy and histological examination revealed papil...
Severe hypokalemia in a child with mild gastroenteritis
Faria, Catarina; Ferreira, Carina; Sarmento, Alzira; Gonçalves, Sara; Rocha, Paula; Duarte, Carlos; Mota, ConceiçãoBackground: Hypokalemia (serum potassium below 3.5 mmol/L) may be caused by several mechanisms. Severe hypokalemia must be immediately managed, as it can have important cardiac repercussions. Clinical case: A previously healthy eight-year-old female, with normal growth and normal-to-low blood pressure, was observed due to persistent abdominal pain, anorexia, and fever two days after overcoming a mild gastroente...
Rituximab use in children with complicated idiopathic nephrotic syndrome - a si...
Moreira, Carla Leal; Baptista, Rita; Sousa, Pedro Maneira; Maciel, Juliana; Costa, Liane; Teixeira, Ana; Costa, Teresa; Matos, Paula; Rocha, LilianaBackground: In children with idiopathic nephrotic syndrome, rituximab can maintain short-term remission allowing steroids and calcineurin inhibitors taper. Methods: We retrospectively reviewed all children receiving rituximab for idiopathic nephrotic syndrome at a tertiary hospital. All patients, except one who received a single dose, had four infusions of 375mg/m2 of rituximab at a one-week interval, minimum f...
Espectro mutacional da cistinose em Portugal, 1998-2017
Ferreira, Filipa; Leal, Inês; Sousa, David; Costa, Teresa; Mota, Conceição; Gomes, Ana Marta; Lopes, Daniela; Macário, Maria do Carmo; Tavares, IsabelA cistinose é uma doença metabólica multisistémica, autossómica recessiva caracterizada por uma acumulação de cistina em diferentes órgãos e tecidos devido a uma deficiência no transporte de cistina para o exterior dos lisossomas. O gene responsável pela doença, CTNS, está localizado no cromossoma 17 e codifica para uma proteína de membrana lisossomal, a cistinosina. Neste trabalho foram estudados doentes não r...
Nephro urology case
Martins, Andreia A.; Afonso, Ivete; Faria, Maria Sameiro; Costa, Teresa; Reis, Armando; Machado, Rui; Mota, ConceiçãoThe Nutcracker Syndrome (NS) originates from the compression of the left renal vein in its trajectory, mostly between the aorta and the superior mesenteric artery, or less frequently between the aorta and the lumbar spine. Although asymptomatic in most cases, it can be a rare cause of hematuria. We present the case of an 11-year-old male adolescent who was referred to a Pediatric Nephrology evaluation for a two...