37 documents found, page 1 of 4
Profiles of motor competence and its perception accuracy among children: associ...
Almeida, Gabriela M.; Luz, Carlos J.; Rodrigues, Luis Paulo; Lopes, Vitor P.; Cordovil, RitaThe main goals of this study were to identify profiles in school-aged children based on actual Motor Competence (MC) and accuracy of Perceived Motor Competence (PMC) and to examine how children with different profiles differ in terms of Physical Fitness (PF) and Body Fat percentage (BF%). The MC of a total of 287 children (51.6% boys, aged between 6 and 10 years-old) was assessed using the Motor Competence Asse...
Upregulation of tRNA-Ser-AGA-2-1 promotes malignant behavior in normal bronchia...
Santos, Mafalda; Fidalgo, Ana; Varanda, Ana Sofia; Soares, Ana Raquel; Almeida, Gabriela M.; Martins, Diana; Mendes, Nuno; Oliveira, CarlaSerine tRNAs (tRNASer) are frequently overexpressed in tumors and associated with poor prognosis and increased risk of recurrence in breast cancer. Impairment of tRNA biogenesis and abundance also impacts proteome homeostasis, and activates protein quality control systems. Herein, we aimed at testing whether increasing tRNASer abundance could foster tumor establishment through activation of the UPR. In order to...
Immunophenotype of gastric tumors unveils a pleiotropic role of regulatory T ce...
Rocha, Sara; Basto, Afonso; Ijsselsteijn, Marieke E.; Teles, Sara P.; Azevedo, Maria M.; Gonçalves, Gilza; Gullo, Irene; Almeida, Gabriela M.Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).; Gastric cancer (GC) patients display increased regulatory T cell (Tregs) numbers in peripheral blood and among tumor-infiltrating lymphocytes. Nevertheless, the r...
Porphyrin modified trastuzumab improves efficacy of HER2 targeted photodynamic ...
Korsak, Barbara; Almeida, Gabriela M.; Rocha, Sara; Pereira, Carla; Mendes, Nuno; Osório, Hugo; Pereira, Patrícia M. R.; Rodrigues, João M. M.Gastric cancer (GC) is the 3rd deadliest cancer worldwide, due to limited treatment options and late diagnosis. Human epidermal growth factor receptor-2 (HER2) is overexpressed in ∼20% of GC cases and anti-HER2 antibody trastuzumab in combination with conventional chemotherapy, is recognized as standard therapy for HER2-positive metastatic GC. This strategy improves GC patients' survival by 2-3 months, however ...
Suillus luteus methanolic extract inhibits cell growth and proliferation of a c...
Santos, Tiago; Tavares, Catarina; Sousa, Diana; Vaz, Josiana A.; Calhelha, Ricardo C.; Martins, Anabela; Almeida, Gabriela M.; Ferreira, Isabel C.F.R.Several edible mushrooms extracts are known to have tumour cell growth inhibitory potential. The objective of this work was to study this potential in extracts of Suillus luteus collected from the Northeast of Portugal. Various extracts were prepared and their effect on tumour cell growth was studied with the SRB assay in four human tumour cell lines: MCF-7 (breast), NCI-H460 (non-small cell lung cancer), AGS (...
Estudo de propriedades antioxidantes, antiproliferativas e indutoras de apoptos...
Vaz, Josiana A.; Almeida, Gabriela M.; Martins, Anabela; Vasconcelos, M. Helena; Ferreira, Isabel C.F.R.Os cogumelos são um importante recurso complementar de ecossistemas florestais e outros, com propriedades nutricionais e medicinais milenarmente reconhecidas. O objetivo deste trabalho foi a avaliação das propriedades bioativas (antioxidantes e potencial inibidor de crescimento de linhas celulares tumorais humanas) de cogumelos silvestres comestíveis provenientes do Nordeste de Portugal. Prepararam-se extratos ...
Suillus luteus methanolic extract inhibits cell growth and proliferation of a c...
Santos, Tiago dos; Tavares, Catarina; Sousa, Diana; Vaz, Josiana A.; Calhelha, Ricardo C.; Martins, Anabela; Almeida, Gabriela M.Several edible mushrooms extracts are known to have tumor cell growth inhibitory potential. The objective of this work was to study this potential in extracts of Suillus luteus collected from the Northeast of Portugal. Various extracts were prepared and their effect on tumor cell growth was studied with the SRB assay in four human tumor cell lines: MCF-7 (breast), NCI-H460 (non-small cell lung cancer), AGS (gas...
Gonoderma luicidium methanolic extract: chemical characterization in phenolic c...
Heleno, Sandrina A.; Tavares, Catarina; Vaz, Josiana A.; Almeida, Gabriela M.; Martins, Anabela; Queiroz, Maria João R. P.; Vasconcelos, M. HelenaFundação para a Ciência e a Tecnologia (FCT, Portugal) and COMPETE/QREN/UE (research project PTDC/AGR-ALI/110062/2009 and research unities PEst-C/QUI/UI0686/2011 and PEst-OE/AGR/UI290/2011) and S.A. Heleno PhD grant (BD/70304/2010) also financed by POPH and FSE
Clitocybe alexandri extract induces cell cycle arrest and apoptosis in a lung c...
Vaz, Josiana A.; Almeida, Gabriela M.; Ferreira, Isabel C.F.R.; Martins, Anabela; Vasconcelos, M. HelenaMushrooms are a possible rich source of biologically active compounds with potential for drug discovery. The aim of this work was to gain further insight into the citotoxicity mechanism of action of Clitocybe alexandri ethanolic extract against a lung cancer cell line (NCI-H460 cells). The effects on cell cycle profile and levels of apoptosis were evaluated by flow cytometry, and the effect on the expression le...
Ganoderma lucidum methanolic extract: chemical characterization in phenolic com...
Heleno, Sandrina A.; Tavares, Catarina; Vaz, Josiana A.; Almeida, Gabriela M.; Martins, Anabela; Queiroz, Maria João R.P.; Vasconcelos, M. HelenaGanoderma lucidum is one of the most extensively studied mushroom species due to its medicinal properties. It has been used as functional food and as chemopreventer in some countries for thousands of years, and became a popular dietary supplement ingredient in Western countries [1]. Some of its pharmacological properties have been related to antitumour properties, attributed to a wide variety of bioactive compo...