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This work presents a numerical and experimental approach in order to predict the thermal behaviour and the performance of typical cellular wooden slabs with rectangular and circular perforations when submitted to fire conditions. For this purpose a 3D numerical model was validated with different experimental tests at real scale obtained in laboratory in four cellular wooden slabs. This study was conducted in accordance with European standard (EN 1365-2, 1999) and using a fire resistance furnace which complies the requirements of European standard (EN 1363-1, 1999). The numerical temperatures show good agreement with experimental results. The numerical model can easily be adjusted for other constructive solutions, to facilitate fire safety tests, in buildings with wooden slabs used in floors or in ceilings applications.