Author(s):
de Oliveira Cardoso, Valéria Maria [UNESP] ; Gremião, Maria Palmira Daflon [UNESP] ; Cury, Beatriz Stringhetti Ferreira [UNESP]
Date: 2020
Persistent ID: http://hdl.handle.net/11449/200019
Origin: Oasisbr
Subject(s): Gellan gum; Mucoadhesive drug delivery systems; Mucoadhesive force; Pig gastric mucin (mucin type II); Retrograded starch; Rheology; Gellan gum; Gellan gum; Mucoadhesive drug delivery systems; Mucoadhesive drug delivery systems; Mucoadhesive force; Mucoadhesive force; Pig gastric mucin (mucin type II); Pig gastric mucin (mucin type II); Retrograded starch; Retrograded starch; Rheology; Rheology
Description
Made available in DSpace on 2020-12-12T01:55:28Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-04-15
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
The design of mucoadhesive drug delivery systems (DDS) based on polysaccharides at nanoscale or microscale is a relevant technological strategy for the mucosal delivery of several drugs. Findings about the potential mucoadhesive ability of these materials and the mechanisms that drive such interactions represents an important advance for the rational modulation of these properties, according to specific uses. The potential mucoadhesive abilities of gellan gum (GG) and retrograded starch (RS) were investigated at pH 1.2 and 6.8, which were considered biorrelevant for the gastrointestinal tract (GIT). The effects of these polysaccharides on the MUC rheology were also addressed. Rheological studies revealed high MUC-GG interactions at both pH values (1.2 and 6.8), expressing a high mucoadhesive ability, mainly in acidic media. MUC-GG interactions were driven, mainly, by hydrogen bonds. At an acidic pH, significant changes occurred in the MUC arrangements due to the strong MUC-GG interactions, as corroborated by scanning electron microscopy (SEM). The rheological behavior of MUC-RS indicated poor interactions between them and MUC arrangements were more preserved as evidenced by SEM. The results of this work indicated that the mixing of GG and RS can be a promising strategy to modulate mucoadhesiveness of DDS, according to specific therapeutic needs.
UNESP - São Paulo State University School of Pharmaceutical Sciences Department of Drugs and Medicines, km 1 Araraquara-Jaú Road
UNESP - São Paulo State University School of Pharmaceutical Sciences Department of Drugs and Medicines, km 1 Araraquara-Jaú Road
FAPESP: 2014/50928-2
FAPESP: 2015/21412-0
FAPESP: 2017/16324-0
CNPq: 465687/2014-8
