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Free radicals are unstable atoms or molecules that can be not only generated under physiologic conditions but also induced by many exogenous compounds. They interact with many molecular and cellular targets and may cause adverse effects owing to oxidative stress, i.e., an imbalance between the generation of oxidizing compounds and the performance of antioxidant defense systems. Nanoparticles are a broad class of materials that include particulate matter ranging in size from 1 to 100 nm and that are applied in numerous fields such as medicine, manufacture, and sustainable energy. These materials have been monitored for efficacy and safety, including around induction of oxidative stress.

Department of Pathology Botucatu Medical School São Paulo State University (UNESP) - Center for Evaluation of Environmental Impact on Human Health (TOXICAM)

Laboratory of Extracellular Matrix and Gene Expression Regulation Department of Structural and Functional Biology - Institute of Biology - UNICAMP

Department of Bioprocesses and Biotechnology College of Agronomy Sciences (FCA) São Paulo State University (UNESP) - Center for Evaluation of Environmental Impact on Human Health (TOXICAM)

Department of Pathology Botucatu Medical School São Paulo State University (UNESP) - Center for Evaluation of Environmental Impact on Human Health (TOXICAM)

Department of Bioprocesses and Biotechnology College of Agronomy Sciences (FCA) São Paulo State University (UNESP) - Center for Evaluation of Environmental Impact on Human Health (TOXICAM)