Autor(es):
Souza, José António Santos [UNESP] ; Alves, Marta M. ; Barbosa, Debora Barros [UNESP] ; Lopes, Maria Manuel ; Pinto, Eugénia ; Figueiral, Maria Helena ; Delbem, Alberto Carlos B [UNESP] ; Mira, Nuno Pereira
Data: 2020
Identificador Persistente: http://hdl.handle.net/11449/200544
Origem: Oasisbr
Assunto(s): Punica granatum; oral candidiasis; phytotherapeutics; silver nanoparticles; ‘green’ synthesis; Punica granatum; Punica granatum; oral candidiasis; oral candidiasis; phytotherapeutics; phytotherapeutics; silver nanoparticles; silver nanoparticles; ‘green’ synthesis; ‘green’ synthesis
Descrição
Made available in DSpace on 2020-12-12T02:09:26Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-06-01
The continuous emergence of Candida strains resistant to currently used antifungals demands the development of new alternatives that could reduce the burden of candidiasis. In this work silver nanoparticles synthesized using a green route are efficiently used, alone or in combination with fluconazole, amphotericin B or nystatine, to inhibit growth of C. albicans and C. glabrata oral clinical strains, including in strains showing resistance to fluconazole. A potent inhibitory effect over biofilm formation prompted by the two Candida species was also observed, including in mature biofilm cells. These results foster the use of phytotherapeutics as effective treatments in oral candidiasis.
São Paulo State University (UNESP) School of Dentistry Araçatuba Department of Pediatric Dentistry and Public Health
Centro de Química Estrutural Instituto Superior Técnico Universidade de Lisboa
São Paulo State University (UNESP) School of Dentistry Araçatuba Department of Dental Materials and Prosthodontics
Faculdade de Farmácia da Universidade de Lisboa Departamento de Microbiologia e Imunologia, Av. Prof. Gama Pinto
Laboratory of Microbiology, Biological Sciences Department, Faculty of Pharmacy of University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal
Interdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR) University of Porto Terminal de Cruzeiros do Porto de Leixões, Avenida General Norton de Matos
Faculty of Dentistry Porto University, Rua Manuel Pereira da Silva
iBB, Institute for Bioengineering and Biosciences, Instituto Superior Técnico - Department of Bioengineering, Universidade de Lisboa, Lisbon, Portugal
São Paulo State University (UNESP) School of Dentistry Araçatuba Department of Pediatric Dentistry and Public Health
São Paulo State University (UNESP) School of Dentistry Araçatuba Department of Dental Materials and Prosthodontics
