Author(s):
Oshiro-Júnior, João A. [UNESP] ; Rodero, Camila [UNESP] ; Hanck-Silva, Gilmar [UNESP] ; Sato, Mariana R. [UNESP] ; Alves, Renata Carolina [UNESP] ; Eloy, Josimar O. ; Chorilli, Marlus [UNESP]
Date: 2020
Persistent ID: http://hdl.handle.net/11449/200570
Origin: Oasisbr
Subject(s): Breast cancer treatment; Extrinsic/physical stimuli; Intrinsic/chemical stimuli; Liposoluble drugs; Near-infrared light (NIR); Stimuli-responsive drug delivery nanocarriers; Breast cancer treatment; Breast cancer treatment; Extrinsic/physical stimuli; Extrinsic/physical stimuli; Intrinsic/chemical stimuli; Intrinsic/chemical stimuli; Liposoluble drugs; Liposoluble drugs; Near-infrared light (NIR); Near-infrared light (NIR); Stimuli-responsive drug delivery nanocarriers; Stimuli-responsive drug delivery nanocarriers
Description
Made available in DSpace on 2020-12-12T02:10:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01
Stimuli-responsive drug-delivery nanocarriers (DDNs) have been increasingly reported in the literature as an alternative for breast cancer therapy. Stimuli-responsive DDNs are developed with materials that present a drastic change in response to intrinsic/chemical stimuli (pH, redox and enzyme) and extrinsic/physical stimuli (ultrasound, Near-infrared (NIR) light, magnetic field and electric current). In addition, they can be developed using different strategies, such as functionalization with signaling molecules, leading to several advantages, such as (a) improved pharmaceutical properties of liposoluble drugs, (b) selectivity with the tumor tissue decreasing systemic toxic effects, (c) controlled release upon different stimuli, which are all fundamental to improving the therapeutic effectiveness of breast cancer treatment. Therefore, this review summarizes the use of stimuli-responsive DDNs in the treatment of breast cancer. We have divided the discussions into intrinsic and extrinsic stimuli and have separately detailed them regarding their definitions and applications. Finally, we aim to address the ability of these stimuli-responsive DDNs to control the drug release in vitro and the influence on breast cancer therapy, evaluated in vivo in breast cancer models.
Department of Drugs and Medicines Faculdade de Ciências Farmacêuticas UNESP-Univ. Estadual Paulista, Campus Araraquara
College of Pharmacy Dentistry and Nursing Department of Pharmacy Federal University of Ceará
Graduation Program in Pharmaceutical Sciences State University of Paraíba
Department of Drugs and Medicines Faculdade de Ciências Farmacêuticas UNESP-Univ. Estadual Paulista, Campus Araraquara
