Autor(es):
Paredes, Joana ; Correia, Ana Luísa ; Ribeiro, Ana Sofia ; Schmitt, Fernando
Data: 2007
Identificador Persistente: https://hdl.handle.net/1822/67736
Origem: RepositóriUM - Universidade do Minho
Assunto(s): Blotting, Western; Breast neoplasms; Cadherins; Catenins; Cell adhesion molecules; Cell Line, Tumor; Humans; Phenotype; Phosphoproteins; Protein isoforms; RNA, Messenger; Reverse transcriptase polymerase chain reaction; Transcription, Genetic; Gene expression regulation, Neoplastic; Breast cancer cells; Cell–cell adhesion; p120-catenin isoforms; cadherin
Descrição
P120-catenin is a member of the Armadillo protein family, which is involved in intercellular adhesion and cell signalling. It directly interacts with the classical cadherins juxtamembrane domain and contributes for both junction formation and its disassembly. Accumulating evidences indicate that p120-catenin is important in tumour formation and progression, although the role of their multiple spliced isoforms in the regulation of cadherin-mediated adhesion of malignant cells is still not well understood. We investigated the expression of p120-catenin isoforms in a collection of breast cancer cell lines with distinct molecular profiles and expressing different cadherins.
