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New 1-hydroxy-1,1-bisphosphonates derived from 1H-pyrazolo[3,4-b]pyridine: synthesis and characterization

Author(s): Teixeira,Fátima C. ; Lucas,Carla ; Curto,M. João M. ; Neves,M. ; Duarte,M. Teresa ; André,Vânia ; Teixeira,António P. S.

Date: 2013

Origin: Oasisbr

Subject(s): bisphosphonates; 1H-pyrazolo[3,4-b]pyridine; spectroscopic characterization; synthesis; X-ray diffractometry studies; bisphosphonates; bisphosphonates; 1H-pyrazolo[3,4-b]pyridine; 1H-pyrazolo[3,4-b]pyridine; spectroscopic characterization; spectroscopic characterization; synthesis; synthesis; X-ray diffractometry studies; X-ray diffractometry studies

Description

A number of 1H-pyrazolo[3,4-b]pyridine derivatives, starting from 2-chloro-3-formyl pyridine, was synthesized to obtain new 1-hydroxybisphosphonates, a class of compounds with potential biological interest. Spectroscopic data were used to characterize all compounds and to identify N-1 and N-2 regioisomers, and mono-and bisphosphonates derivatives. X-ray diffractometry studies of compound 7a confirmed the proposed structure.

Document Type Journal article
Language English

Document details

New 1-hydroxy-1,1-bisphosphonates derived from 1H-pyrazolo[3,4-b]pyridine: synthesis and characterization

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