Author(s):
Bergman, Marie-Louise ; Lopes-Carvalho, Thiago ; Martins, Ana-Catarina ; Grieco, Fabio A. ; Eizirik, Décio L. ; Demengeot, Jocelyne
Date: 2017
Persistent ID: http://hdl.handle.net/10400.7/820
Origin: ARCA - Access to Research and Communication Annals
Project/scholarship:
info:eu-repo/grantAgreement/EC/FP7/241447/EU;
Subject(s): Animals; Autoantibodies; Diabetes Mellitus, Type 1; Female; Hyperglycemia; Insulin; Insulin Antibodies; Mice, Inbred NOD; Microscopy, Fluorescence; Vaccination; Epitopes; Autoimmunity
Description
The deposited article version contains attached the supplementary materials within the pdf.
Daniel et al. (https://doi.org/10.1084/jem.20110574) have previously published in JEM a study on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Our study now challenges these results and shows that osmotic pump delivery of the modified insulin peptide R22E did not prevent hyperglycemia, accelerated disease onset, increased its incidence, and worsened insulitis.
European Union’s (EU FP7) Large-Scale Focused Collaborative Research Project on Natural Immunomodulators as Novel Immunotherapies for Type 1 Diabetes grant: (NAIMIT, 241447).