Author(s): Souza, Andrews Victor Almeida ; Ferrera, Conrado ; Puga, Hélder ; Lima, Rui A. ; Ribeiro, J.E. ; Souza, Maria Sabrina
Date: 2023
Persistent ID: http://hdl.handle.net/10198/26273
Origin: Biblioteca Digital do IPB
Subject(s): Cerebral aneurysm; In vitro tests; PDMS flow biomodels
Cerebral aneurysm is an abnormal dilatation of the blood vessel which affects a high percentage of the worldwide population. One way to investigate this pathology is using in vivo techniques, but these types of experiments have a high cost and low reproducibility. Thus, to understand the local hemodynamics of brain aneurysms, it is imperative to manufacture in vitro models that simulate real brain aneurysms. These biomodels are suitable for experimental testing, as well as for evaluating and validating computational models. In this work, was manufactured a biomodel of a cerebral aneurysm made by polydimethylsiloxane (PDMS), combining rapid prototyping technology with a PDMS gravity casting process. Experimental flow visualizations were performed at different flow rates. The flow visualizations results have shown that there is a transition from laminar to turbulent flow for a flow rate near 6 ml/min. The proposed PDMS biomodels have shown the ability to perform flow visualizations and have the potential to help the development and validation of computational models.
