Prodrug Systems (I): Lipid-based Doxorubicin Prodrugs and their nanodelivery systems

• Author(s): Olim, Filipe ; Neves, Ana Rute ; Wang, Zhao ; Sun, Jingjing ; Tomás, Helena ; Sheng, Ruilong
• Date: 2020
• Persistent ID: http://hdl.handle.net/10400.13/3820
• Origin: DigitUMa - Repositório da Universidade da Madeira
• Subject(s): Lipid; Doxorubicin; Prodrugs; Stimuli-responsive; Drug co-delivery; Nanosystems; .; Faculdade de Ciências Exatas e da Engenharia; Centro de Química da Madeira
• Document Type: Journal article
• Language: English
• Contributor(s): DigitUMa

Description

Using natural lipids to covalently connect with antitumor agents to construct lipid-based molecular prodrugs and their nanosystems is a promising research frontier for sustainable medicinal chemistry, nanobiotechnology and tumor chemotherapy. This paper reviewed recent progress of lipid-based doxorubicin (molecular) prodrugs and their nanodelivery systems, including lipid-doxorubicin prodrugs, stimuli-responsive lipid-doxorubicin prodrugs, and lipid-doxorubicin prodrug-based drug co-delivery nanosystems. Additionally, possible future research outlooks in this field were also discussed.