Autor(es): Marques, Cíntia ; Som, Claudia ; Schmutz, Mélanie ; Borges, Olga ; Borchard, Gerrit
Data: 2020
Identificador Persistente: https://hdl.handle.net/10316/106099
Origem: Estudo Geral - Universidade de Coimbra
Assunto(s): safe by design; polymeric drug carriers; chitosan; insulin; protein drug delivery
Efficacy and safety of nanomedicines based on polymeric (bio)materials will benefit from a rational implementation of a Safe-by-Design (SbD) approach throughout their development. In order to achieve this goal, however, a standardization of preparation and characterization methods and their accurate reporting is needed. Focusing on the example of chitosan, a biopolymer derived from chitin and frequently used in drug and vaccine delivery vector preparation, this review discusses the challenges still to be met and overcome prior to a successful implementation of the SbD approach to the preparation of chitosan-based protein drug delivery systems.
