Author(s): Ribeiro, João L. P. ; Alves, Cláudia ; Cardoso, Ana L. ; Lopes, Susana M. M. ; Pinho e Melo, Teresa M. V. D.
Date: 2021
Persistent ID: https://hdl.handle.net/10316/107507
Origin: Estudo Geral - Universidade de Coimbra
Subject(s): Chiral amines; asymmetric reduction; enantioselective reduction; diastereoselective reduction; oximes; chiral hydroxylamines; hydrazones; chiral hydrazines
The asymmetric reduction of oximes and hydrazones is an attractive and versatile strategy for the synthesis of chiral amines, which are valuable building blocks in organic synthesis. This review summarizes the relevant developments, made in the last decade, on the enantioselective and diastereoselective reduction of oximes and hydrazones involving metal-catalyzed hydrogenation/hydrogenolysis reactions, hydride donor reactions, and electrochemical reactions.
