Autor(es): Branco, Ana ; Moniz, Inês ; Santos, João Ramalho
Data: 2023
Identificador Persistente: https://hdl.handle.net/10316/113184
Origem: Estudo Geral - Universidade de Coimbra
Assunto(s): Mesenchymal stem cell; Aging; Mitochondria; Stem Cells; Cellular Senescence; Mitochondria
Organismal aging is impacted by the deterioration of tissue turnover mechanisms due, in part, to the decline in stem cell function. This decline can be related to mitochondrial dysfunction and underlying energetic defects that, in concert, help drive biological aging. Thus, mitochondria have been described as a potential interventional target to hinder the loss of stem cell robustness, and subsequently, decrease tissue turnover decline and age-associated pathologies. In this review, we focused our analysis on the most recent literature on mitochondria and stem cell aging and discuss the potential benefits of targeting mitochondria in preventing stem cell dysfunction and thus influencing aging.
