Author(s): Liu, Q. ; Xie, F. ; Siedlak, S. L. ; Nunomura, A. ; Honda, K. ; Moreira, P. I. ; Zhua, X. ; Smith, M. A. ; Perry, G.
Date: 2004
Persistent ID: https://hdl.handle.net/10316/7895
Origin: Estudo Geral - Universidade de Coimbra
Document details
Neurofilament proteins in neurodegenerative diseases
Description
The function of neurofilaments, the major component in large myelinated neurons, is not well understood even though they were discovered as structures over 100 years ago. Recent studies have suggested that neuro-filaments are closely related to many neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson disease Alzheimer disease, and diabetes. Using in vitro assays, cultures and transgenic mice, these studies provided new insights into neurofilament function. The function of each subunit, the relationship of neurofilaments with other cytoskeletal elements and their clinical significance are topics of increasing attention.
Document Type
Journal article
Language English
Language English
