Author(s): Morais, Damila Rodrigues de ; Bataglion, Giovana Anceski, 1986- ; Eberlin, Marcos Nogueira, 1959-
Date: 2016
Persistent ID: https://hdl.handle.net/20.500.12733/1142
Origin: Oasisbr
Subject(s): Cádmio; Rato; Genotoxicidade; Cadmium; Rats; Genotoxicity; Purple carrot; Oxidative stress; Artigo de pesquisa
Agradecimentos: The authors are grateful to Hansen Company (Campinas, SP,Brazil) for providing us the purple carrot extract. This study was supported by CNPq (Conselho Nacional de Desen-volvimento Cientifico e Tecnologico) and CAPES (Coordenac ¸ ão deAperfeic ¸ oamento de Pessoal de NIvel Superior)
Abstract: The aim of this study was to investigate if purple carrot extract is able to protect against the noxious activities induced by cadmium exposure in multiple organs of rats. For this purpose, histopathological analysis, genotoxicity and oxidative status were investigated in this setting. A total of twenty Wistar rats weighing 250 g on the average, and 8 weeks age were distributed into four groups (n = 5), as follows: Control group (non-treated group, CTRL); Cadmium group (Cd) and Purple carrot extract groups at 400 mg/L or 800 mg/L. Histopathological analysis revealed that liver from animals treated with purple carrot extract improved tissue degeneration induced by cadmium intoxication. Genetic damage was reduced in blood and hepatocytes as depicted by comet and micronucleus assays in animals treated with purple carrot extract. SOD-CuZn and cytocrome C gene expression increased in groups treated with purple carrot extract. Purple carrot extract also reduced the 8OHdG levels in liver cells when compared to cadmium group. Taken together, our results demonstrate that purple carrot extract is able to protect against cadmium intoxication by means of reducing tissue regeneration, genotoxicity and oxidative stress in multiple organs of Wistar rats
CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ
COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES
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