Author(s): Aragão, Gislei Frota ; Nonato, Dayanne Terra Tenório ; Ponte, Edson Lopes da ; Sales, Jonathan Rodrigues ; Alencar, Daniel Barroso ; Sampaio, Silvana Saker ; Camelo Chaves, Edna Maria ; Assreuy, Ana Maria Sampaio
Date: 2016
Origin: Oasisbr
Subject(s): acute inflammatory process; antinociception; epilepsy; red seaweed
This study aimed to investigate the EEAm effect in mice models of nociception, inflammation and in behavioral tests evaluating the central nervous system. EEAm had inhibitory effects in the following tests: acetic acid-induced writhing (78%); formalin (62% - inflammatory phase); open field (46%). EEAm increased the nociceptive latency (56%) in tail flick test and increased the death-latency by 36% in the pentylenetetrazole-induced seizure model. Moreover, EEAm inhibited paw edema (82%) and peritonitis (45%) induced by carrageenan. In conclusion, EEAm presents antinociceptive, anti-inflammatory and anticonvulsant effects involving peripheral and central-acting mechanisms in mice.
