Author(s): Gomes, Ana ; Teixeira, Cátia ; Ferraz, Ricardo ; Prudêncio, Cristina ; Gomes, Paula
Date: 2017
Persistent ID: http://hdl.handle.net/10400.22/13749
Origin: Repositório Científico do Instituto Politécnico do Porto
Subject(s): Anti-Infective Agents; Diabetic Foot; Humans; Peptides; Skin; Skin Diseases; Wound Healing
As the incidence of diabetes continues to increase in the western world, the prevalence of chronic wounds related to this condition continues to be a major focus of wound care research. Additionally, over 50% of chronic wounds exhibit signs and symptoms that are consistent with localized bacterial biofilms underlying severe infections that contribute to tissue destruction, delayed wound-healing and other serious complications. Most current biomedical approaches for advanced wound care aim at providing antimicrobial protection to the open wound together with a matrix scaffold (often collagen-based) to boost reestablishment of the skin tissue. Therefore, the present review is focused on the efforts that have been made over the past years to find peptides possessing wound-healing properties, towards the development of new and effective wound care treatments for diabetic foot ulcers and other skin and soft tissue infections.
