Author(s): Araújo, Bruna ; Caridade-Silva, Rita ; Soares-Guedes, Carla ; Martins-Macedo, Joana ; Gomes, Eduardo D. ; Monteiro, Susana ; Teixeira, Fábio G.
Date: 2022
Persistent ID: http://hdl.handle.net/10400.22/22072
Origin: Repositório Científico do Instituto Politécnico do Porto
Subject(s): Parkinson’s disease Inflammatory cells; Neuroinflammation; Acute and chronic responses; Gut–brain axis
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder world wide. Clinically, it is characterized by a progressive degeneration of dopaminergic neurons (DAn), resulting in severe motor complications. Preclinical and clinical studies have indicated that neuroin flammation can play a role in PD pathophysiology, being associated with its onset and progression. Nevertheless, several key points concerning the neuroinflammatory process in PD remain to be answered. Bearing this in mind, in the present review, we cover the impact of neuroinflammation on PD by exploring the role of inflammatory cells (i.e., microglia and astrocytes) and the interconnections between the brain and the peripheral system. Furthermore, we discuss both the innate and adaptive immune responses regarding PD pathology and explore the gut–brain axis communication and its influence on the progression of the disease.
