Author(s): Lopes, Inês ; Meireles, Isabel ; Rocha, Rafaela ; Medeiros, Rui ; Cerqueira, Fátima
Date: 2025
Persistent ID: http://hdl.handle.net/10400.22/30660
Origin: Repositório Científico do Instituto Politécnico do Porto
Subject(s): Cancer; Drug resistance; Dimeric flavonoids; Hallmarks
Evidence found in the literature indicates that dimeric flavonoids constitute important therapeutic options against cancer. Using these molecules to prevent cancer progression might be a novel and promising therapeutic approach with advantages like fewer side effects, easy access in nature, overall health benefits and overcoming drug resistance. Cancer is a complex disease and still not understood, but there are some common mechanisms and biological characteristics underlying tumor progression that have been scrutinized over the years. This information was summarized in a conceptual framework designated as hallmarks of cancer. Dimeric flavonoids exert biological effects in several pathways involved in cancer hallmarks including cell growth, cell cycle, apoptosis, metastasis and metabolism.
