Autor(es): Thieleke-Matos, C ; Osório, DS ; Carvalho, AX ; Morais-de-Sá, E
Data: 2017
Identificador Persistente: http://hdl.handle.net/10216/110887
Origem: Repositório Aberto da Universidade do Porto
Assunto(s): Animals; Asymmetric cell division; Body patterning; Cell shape; Cytokinesis; Humans; Models, Biological
Cytokinesis completes cell division by physically separating the contents of the mother cell between the two daughter cells. This event requires the highly coordinated reorganization of the cytoskeleton within a precise window of time to ensure faithful genomic segregation. In addition, recent progress in the field highlighted the importance of cytokinesis in providing particularly important cues in the context of multicellular tissues. The organization of the cytokinetic machinery and the asymmetric localization or inheritance of the midbody remnants is critical to define the spatial distribution of mechanical and biochemical signals. After a brief overview of the conserved steps of animal cytokinesis, we review the mechanisms controlling polarized cytokinesis focusing on the challenges of epithelial cytokinesis. Finally, we discuss the significance of these asymmetries in defining embryonic body axes, determining cell fate, and ensuring the correct propagation of epithelial organization during proliferation.
