Autor(es): Battista, Migliori, G ; Tiberi, S ; Zumla, A ; Petersen, E ; Muhwa Chakaya, J ; Wejse, C ; Muñoz Torrico, M ; Duarte, R
Data: 2020
Identificador Persistente: https://hdl.handle.net/10216/143204
Origem: Repositório Aberto da Universidade do Porto
Assunto(s): Diagnosis; MDR-TB; Prevention; Rehabilitation of sequelae; Treatment; XDR-TB
The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health staff with an updated and easy-to-consult document arising from consensus of Global Tuberculosis Network (GTN) experts. The core published documents and guidelines have been reviewed, including the recently published MDR-TB WHO rapid advice and ATS/CDC/ERS/IDSA guidelines. After a rapid review of epidemiology and risk factors, the clinical priorities on MDR-TB diagnosis (including whole genome sequencing and drug-susceptibility testing interpretations) and treatment (treatment design and management, TB in children) are discussed. Furthermore, the review comprehensively describes the latest information on contact tracing and LTBI management in MDR-TB contacts, while providing guidance on post-treatment functional evaluation and rehabilitation of TB sequelae, infection control and other public health priorities.
