Author(s): Leandro, MKDNS ; Moura, JVB ; Freire, PdTC ; Vega, ML ; Lima, CdL ; Hidalgo, ÁA ; Araújo, ACJ ; Freitas, PR ; Paulo, CLR ; Sousa, AK ; Rocha, JE ; Leandro, LMG ; Silva, ROM ; Martins, N ; Coutinho, HDM
Date: 2021
Persistent ID: https://hdl.handle.net/10216/153786
Origin: Repositório Aberto da Universidade do Porto
Subject(s): Antibacterial agent; Antibiotic resistance; Bismuth tungstate; Structural properties
Background: Pathogenic microorganisms are causing increasing cases of mortality and morbidity, along with alarming rates of ineffectiveness as a result of acquired antimicrobial resistance. Bi2WO6 showed good potential to be used as an antibacterial substance when exposed to visible light. This study demonstrates for the first time the dimension-dependent antibacterial activity of layered Bi2WO6 nanosheets. Materials and methods: The synthesized layered Bi2WO6 nanosheets were prepared by the hydrothermal method and characterized by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), atomic force microscopy (AFM), and Raman and Fourier transform infrared spectroscopy (FTIR). Antibacterial and antibiotic-modulation activities were performed in triplicate by the microdilution method associated with visible light irradiation (LEDs). Results: Bi2WO6 nanosheets were effective against all types of bacteria tested, with MIC values of 256 µg/mL against Escherichia coli standard and resistant strains, and 256 µg/mL and 32 µg/mL against Staphylococcus aureus standard and resistant strains, respectively. Two-dimensional (2D) Bi2WO6 nanosheets showed antibacterial efficiency against both strains studied without the presence of light. Conclusions: Layered Bi2WO6 nanosheets revealed dimension-dependent antibacterial activity of the Bi2WO6 system.
