Short and Extended Provocation Tests Have Similar Negative Predictive Value in Non-Immediate Hypersensitivity to Beta-Lactams in Children

• Author(s): Regateiro, FS ; Rezende, I ; Pinto, N ; Abreu, C ; Carreiro-Martins, P ; Gomes, ER
• Date: 2019
• Persistent ID: http://hdl.handle.net/10400.17/3439
• Origin: Repositório do Centro Hospitalar de Lisboa Central, EPE
• Subject(s): Allergens; Anti-Bacterial Agents; Bronchial Provocation Tests; Child; Child, Preschool; Drug Hypersensitivity; Drug Substitution; Female; Humans; Hypersensitivity, Delayed; Male; Predictive Value of Tests; Prognosis; Skin Tests; beta-Lactams; HDE ALER
• Document Type: Journal article
• Language: English
• Contributor(s): Repositório da Unidade Local de Saúde São José

Description

Drug provocation tests (DPTs) are the gold-standard method to diagnose non-immediate hypersensitivity reactions (NIHSR) to beta-lactam antibiotics (BL) in children. Our aim was to compare the negative predictive value (NPV) of one-day (short) DPT versus 3-7 days (extended) DPT for the diagnosis of NIHSR to BL in paediatric age. A secondary aim was to compare confidence on drug re-exposure after short and extended negative DPTs.