Nephrotic Syndrome and Waldenstrom’s Macroglobulinemia: A Case Report

• Author(s): Oliveira, Ana Isabel ; Azevedo, Ana ; Stock da Cunha, Teresa ; Góis, Mário ; Pidal, Ana
• Date: 2023
• Persistent ID: http://hdl.handle.net/10400.17/5215
• Origin: Repositório do Centro Hospitalar de Lisboa Central, EPE
• Document Type: Text
• Language: English
• Contributor(s): Repositório da Unidade Local de Saúde São José

Description

Waldenstrom’s macroglobulinemia (WM) is an IgM associated lymphoplasmacytic lymphoma and kidney disease is a rare complication. We report a case of a 41-year-old male with a history of WM diagnosed 16 years ago, currently with no indication for treatment. The patient presented with nephrotic syndrome and acute kidney injury, hypertension, and multiple lymphadenopathies. A kidney biopsy was performed, showing minimal change disease with lymphomatous infiltration of B-lymphocytes CD20+. Therapy with bortezomib, dexametahasone and rituximab was started and after 6 months of follow-up he presented progressive recovery of renal function and remission of proteinuria. This case illustrates the importance of screening renal disease in WM patients. A kidney biopsy should be performed in those presenting with otherwise unexplained renal failure and/or nephrotic syndrome.