Author(s): Queiroz, Guilherme ; Monteiro, Celdidy ; Manco, Licínio ; Relvas, Luís ; Trovoada, Maria de Jesus ; Leite, Andreia ; Bento, Celeste
Date: 2024
Persistent ID: http://hdl.handle.net/10400.18/10320
Origin: Repositório Científico do Instituto Nacional de Saúde
Subject(s): Cluster Sampling; Genetics; Haemoglobinopathies; Sickle Cell Disease; Sub-saharian Africa; Anemia Células Falciformes; São Tomé e Príncipe; Determinantes da Saúde e da Doença; Estados de Saúde e de Doença
Background Sickle Cell Disorder is Africa’s most prevalent genetic disease. Yet, it remains a neglected condition, with high mortality under-five, and a lack of population-based studies in the region. This is the first of its kind in São Tomé e Príncipe, aiming to estimate the prevalence of sickle cell trait and other haemoglobin variants in women of reproductive age and its associated factors. Methods: We conducted a cluster survey in 35 neighbourhoods. Haemoglobin was assessed through point-of-care capillary electrophoresis or high-performance liquid chromatography, and sociodemographic data through questionnaires. The weighted prevalence of sickle cell trait (HbAS) and HbC carriers was estimated with a 95% confidence interval (95% CI). We calculated weighted prevalence ratios (95% CI) through robust Poisson regression for its association with age and individual and collective genetic heritage. Findings: The prevalence of sickle cell trait in women of reproductive age in São Tomé e Príncipe (n = 376) was 13.45% (95% CI: 9.05-19.00). The prevalence of HbC carriers was 8.00% (95% CI: 4.71-12.00). Older age and speaking Forro or Angolar were positively associated with having sickle cell trait. Interpretation: The prevalence of sickle cell trait in São Tomé e Príncipe ranks high in the West African region. The country should follow international guidelines, implementing newborn screening and comprehensive healthcare management.
