Author(s):
Henriques, João ; Mixão, Verónica ; Cabrita, Joana ; Duarte, Tiago Isidoro ; Sequeira, Tânia ; Cardoso, Sofia ; Germano, Nuno ; Dias, Liliana ; Bento, Luís ; Duarte, Sílvia ; Veríssimo, Cristina ; Gomes, João Paulo ; Sabino, Raquel
Date: 2023
Persistent ID: http://hdl.handle.net/10400.18/9095
Origin: Repositório Científico do Instituto Nacional de Saúde
Subject(s): Candida auris; Whole-genome Sequencing; Antifungal Resistances; Infecções Sistémicas e Zoonoses; Resistência aos Antimicrobianos; Portugal
Description
Candida auris is an opportunistic human pathogen that has rapidly spread to multiple countries and continents and has been associated with a high number of nosocomial outbreaks. Herein, we report the first case of C. auris in Portugal, which was associated with a patient transferred from Angola to an ICU in Portugal for liver transplantation after a SARS-CoV-2 infection. C. auris was isolated during the course of bronchoalveolar lavage, and it was subjected to antifungal susceptibility testing and whole-genome sequence analysis. This isolate presents low susceptibility to azoles and belongs to the genetic clade III with a phylogenetic placement close to African isolates. Although clade III has already been reported in Europe, taking into account the patient’s clinical history, we cannot discard the possibility that the patient’s colonization/infection occurred in Angola, prior to admission in the Portuguese hospital. Considering that C. auris is a fungal pathogen referenced by WHO as a critical priority, this case reinforces the need for continuous surveillance in a hospital setting
